abstract：:A new high-pressure liquid chromatographic method was developed for the simultaneous determination of rubidazone and daunorubicin in human plasma at concentrations as low as 60 ng/ml. Clinical toxicity and the stability of rubidazone were studied in nine patients with advanced solid tumors. Rubidazone was administered...

journal_title：Cancer research

authors： Kovach JS,Ames MM,Sternad ML,O'Connell MJ

更新日期：1979-03-01 00:00:00

abstract：:Normal persons with a history of close contact with cancer patients often given positive responses in tests for specific tumor immunity. The present study was designed to establish the immunological relevance of such reactivity. Leukocyte adherence inhibition analysis was used to test responses of osteosarcoma (OS)-po...

journal_title：Cancer research

authors： Powell A,Sloss AM,Makley JT

更新日期：1979-02-01 00:00:00

abstract：:Cellular immune competence was found to be impaired in previous studies of patients with malignant brain tumors. In patients with nonneural tumors, we recently found that serum levels of acute-phase proteins were related to immune status as well as to tumor extent. To determine whether the serum proteins in patients w...

journal_title：Cancer research

authors： Weiss JF,Morantz RA,Bradley WP,Chretien PB

更新日期：1979-02-01 00:00:00

abstract：:A glomerulopathy in hamsters bearing human epithelial tumors is described. The tumors resulted from the s.c. implantation of human heteroploid cells (MA160) derived originally from a benign prostatic adenoma. The renal immunomorphological and ultrastructural changes include expansion of mesangial matrix and cellularit...

journal_title：Cancer research

authors： Richman AV,Alexander RW

更新日期：1979-02-01 00:00:00

abstract：:Specific immunity to Rous virus-induced sarcoma (RSL) was investigated by the tube leukocyte adherence inhibition (LAI) assay in rats immunized with Bacillus Calmette-Guérin (BCG). Peritoneal cells from Lewis rats immunized s.c. with BCG gave positive reactions in the tube LAI assay with the antigen prepared from RSL ...

journal_title：Cancer research

authors： Holán V,Chutná J,Hasek M

更新日期：1979-02-01 00:00:00

abstract：:We used three techniques to examine excision repair in human cells treated with ultraviolet radiation, N-acetoxy-2-acetylaminofluorene, and a combination of the two. The three techniques gave similar results. Two types of human cells were used: (a) excision repair proficient (normal human fibroblasts and xeroderma pig...

journal_title：Cancer research

authors： Ahmed FE,Setlow RB

更新日期：1979-02-01 00:00:00

abstract：:The presence of specific antitumor immunity was examined by the tube leukocyte adherence inhibition (LAI) assay in patients with carcinomas of the larynx. Peripheral blood leukocytes (PBL) from patients with larynx cancer gave positive reactions in the LAI assay with the antigen prepared from the carcinoma of the lary...

journal_title：Cancer research

authors： Holán V,Síbl O,Hasek M

更新日期：1979-02-01 00:00:00

abstract：:Rabbit skin was infected with Shope papilloma virus and grafted orthotopically to nude mice. Typical Shope rabbit papillomas developed in most of the grafts, but similarly treated nude mouse skin grafts were not altered. These results demonstrated that xenogeneic tissues retained susceptibility to oncogenic agents aft...

journal_title：Cancer research

authors： Kreider JW,Bartlett GL,Sharkey FE

更新日期：1979-01-01 00:00:00

abstract：:Peripheral blood myeloblasts from five patients with acute myeloblastic leukemia and peripheral remission leukocytes from two of these patients were radiolabeled by the lactoperoxidase-catalyzed surface radioiodination technique and incubated in a nutrient medium at 37 degrees. Radioactive materials shed from viable c...

journal_title：Cancer research

authors： Taub RN,Roncari DA,Baker MA

更新日期：1978-12-01 00:00:00

abstract：:In the chemotherapy of infectious diseases, selective toxicity has been achieved by designing curative regimens based on pharmacokinetic data. Selective toxicity of antitumor drugs has been demonstrated for rapidly growing large growth fraction tumors occurring in patients under age 30. In these tumors curative schedu...

journal_title：Cancer research

authors： Zubrod CG

更新日期：1978-12-01 00:00:00

abstract：:Pyruvate kinase isozymes were studied in normal brain tissue (both fetal and adult) and in meningiomas and malignant gliomas. In fetal brain five different forms could be detected by electrophoresis (K4, K3M, K2M2, KM3, and M4). In adult brain the M4-type, K3M hybrid, and K4-type are present; the M isozyme is largely ...

journal_title：Cancer research

authors： van Veelen CW,Verbiest H,Vlug AM,Rijksen G,Staal GE

更新日期：1978-12-01 00:00:00

abstract：:It has been postulated that the intestinal anaerobes play a role in the etiology of large bowel cancer. This study was designed to characterize and compare the fecal anaerobes of patients with large bowel cancer, patients with nonhereditary large bowel polyps, and healthy control subjects. Although some distributional...

journal_title：Cancer research

authors： Mastromarino AJ,Reddy BS,Wynder EL

更新日期：1978-12-01 00:00:00

abstract：:We have studied glycosyltransferase activities in human lymphocytes stimulated with the plant mitogens E-phytohemagglutinin or concanavalin A (Con A) and have compared the results with activities found in resting lymphocytes. Compared to resting lymphocytes, Con A-stimulated lymphocytes possess an enhanced capacity to...

journal_title：Cancer research

authors： Speckart SF,Boldt DH,Ryerson KL

更新日期：1978-12-01 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00

abstract：:Normal young and postmenopausal women were placed into groups according to the ratio of the estrogens in their urine. Women whose ratio was greater than 1.3 if young and greater than 3.2 if postmenopausal were compared to women whose ratio was less than 0.7 and less than 2.1 for young and postmenopausal, respectively....

journal_title：Cancer research

authors： Longcope C,Pratt JH

更新日期：1978-11-01 00:00:00

abstract：:An experimental system designed for tracing the estradiol kinetics in target cells by specific antibodies has been applied to human breast cancer. Several major defects of the estradiol receptor mechanism have been demonstrated. The detected changes (lack of cytoplasmic receptors, impaired nuclear transfer of estradio...

journal_title：Cancer research

authors： Nenci I

更新日期：1978-11-01 00:00:00

abstract：:ZR-75-1, a human breast cancer cell line, has been grown in hormone-supplemented medium without serum. The factors required for optimal growth include 17beta-estradiol, insulin, transferrin, dexamethasone, and L-triiodothyronine. If estradiol, insulin, or L-triiodothyronine is omitted, cells cease division within 7 da...

journal_title：Cancer research

authors： Allegra JC,Lippman ME

更新日期：1978-11-01 00:00:00

abstract：:Fluorescent-labeled hormones can be used to study hormone-receptor interactions by means of fluorescence polarization, visualization by fluorescence microscopy, or separation methods, e.g., dextran-coated charcoal. Subcellular fragments, single cells, and tissue preparations are amenable to study; in this work rat ute...

journal_title：Cancer research

authors： Dandliker WB,Brawn RJ,Hsu ML,Brawn PN,Levin J,Meyers CY,Kolb VM

更新日期：1978-11-01 00:00:00

abstract：:Amino acid analysis of the culture medium was carried out in a human leukemic lymphoblastoid cell line (REH) established from the lymphoblasts of a patient with acute lymphoid leukemia. The results are compared with those of a reference cell line (LHN13) established from normal human lymphocytes. The most striking dif...

journal_title：Cancer research

authors： Lorans G,Rosenfeld C,Petitou M,Phan-Dinh-Tuy F,Mathé G

更新日期：1978-11-01 00:00:00

abstract：:Cloned cell lines derived from the androgen-responsive Shionogi 115 mouse mammary carcinoma, when cultured in the presence of 3.5 X 10(-8) M testosterone, retain their responsiveness to testosterone and 5alpha-dihydrotestosterone and exhibit fibroblast-like morphology; their growth is poorly regulated by cell density....

journal_title：Cancer research

authors： Yates J,King RJ

更新日期：1978-11-01 00:00:00

abstract：:A human colony-stimulating factor (CSF) producing cell line, T3M-1, has been established from explant cultures of a human squamous cell carcinoma of the oral cavity that secretes human CSF. It has been continously propagated during the past 15 months. The cells grew in a monolayered sheet with about 17 hr of populatio...

journal_title：Cancer research

authors： Okabe T,Sato N,Kondo Y,Asano S,Ohsawa N,Kosaka K,Ueyama Y

更新日期：1978-11-01 00:00:00

abstract：:Mice fed a diet containing 0.3 or 0.03% triethanolamine developed malignant tumors. Females showed a high incidence of tumors in lymphoid tissues, while this type was absent in males. Tumors in other tissues were produced at a considerable rate in both sexes, but no hepatoma was found. Triethanolamine was not mutageni...

journal_title：Cancer research

authors： Hoshino H,Tanooka H

更新日期：1978-11-01 00:00:00

abstract：:The pharmacology of high-dose 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) has been studied by radiochemical and chromatographic techniques in eight patients. Plasma disappearance of FT was exponential, with a half-life of 8.8 hr. Plasma concentrations of 5-fluorouracil (FUra) were sustained at 12.8 nmol/ml (1.7 micro...

journal_title：Cancer research

authors： Benvenuto JA,Lu K,Hall SW,Benjamin RS,Loo TL

更新日期：1978-11-01 00:00:00

abstract：:Anguidine is a fungal metabolite with antitumor activity in a murine colon cancer model. Because of disappointing results in clinical trials, we analyzed the lethal and cytokinetic effects of anguidine on cultured human colon cancer cells. The studies revealed a moderate reduction in survival only after prolonged drug...

journal_title：Cancer research

authors： Dosik GM,Barlogie B,Johnston DA,Murphy WK,Drewinko B

更新日期：1978-10-01 00:00:00

abstract：:Cell systems as different as normal human blood lymphocytes and frog auricles release spontaneously a nucleoprotein complex in their culture medium. This release seems to be an active mechanism that is unrelated to cell death. The presence of RNA in this complex is demonstrated. The amount of extracellular RNA is regu...

journal_title：Cancer research

authors： Stroun M,Anker P,Beljanski M,Henri J,Lederrey C,Ojha M,Maurice PA

更新日期：1978-10-01 00:00:00

abstract：:The tumorigenicity of dexamethasone-treated tissue-cultured mammary tumor cells was compared to that of untreated mammary tumor cells. The dexamethasone-induced cells progressed faster in normal syngeneic animals than did untreated mammary tumor cells. The fact that the growth rate differential was also observed in at...

journal_title：Cancer research

authors： Gillette RW,Wunderlich DA

更新日期：1978-10-01 00:00:00

abstract：:By the use of a variety of cell culture and separation methods, four cell lines were isolated from a single autochthonous BALB/cfC3H mammary tumor. These lines differ markedly from each other in culture morphology, various in vitro growth properties, expression of murine mammary tumor virus antigen, and karyotype, yet...

journal_title：Cancer research

authors： Dexter DL,Kowalski HM,Blazar BA,Fligiel Z,Vogel R,Heppner GH

更新日期：1978-10-01 00:00:00

abstract：:Bifunctional alkylating agents are known to produce cross-links between DNA and protein and between paired DNA strands. The possibility of discriminating these two classes of cross-links in L1210 cells treated with haloethylnitrosoureas or nitrogen mustard was explored with the alkaline elution technique. Two classes ...

journal_title：Cancer research

authors： Ewig RA,Kohn KW

更新日期：1978-10-01 00:00:00

abstract：:Two leukemogenic viral populations were derived from a radiation leukemia virus of the C57BL mouse. One (FB), in which only B-tropic virus could be detected, was obtained in vivo by serial passage of cell-free extract in newborn rats. The second (3C), a complex containing at least B-tropic and xenotropic viruses, was ...

journal_title：Cancer research

authors： Janowski M,Astier T,Guillemain B,Baugnet-Mahieu L,Duplan JF,Maisin JR

更新日期：1978-10-01 00:00:00

abstract：:Two continuous retinoblastoma cell lines were observed by scanning electron microscopy. Both cell lines spontaneously grow as a suspension of round cells in clusters, chains, and unique ring (rosette) formations. Scanning electron microscopy of suspension cells reveals some variation in the number and frequency of sur...

journal_title：Cancer research

authors： McFall RC,Nagy RM,Nagle BT,McGreevy LM

更新日期：1978-09-01 00:00:00

abstract：:The incidence, distribution, size, and histopathology of grossly visible colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed either a chemically defined fiber-free diet or a nutritionally and calorically equivalent diet containing a purified fiber component, microcrys...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1978-09-01 00:00:00

abstract：:Cultured normal and malignant human lung cells were examined for their different sensitivities to the cytocidal action of nine antitumor and three non-antitumor agents. The malignant cells were killed preferentially at lower concentrations and in a shorter time with each antitumor agent, Adriamycin, neocarzinostatin, ...

journal_title：Cancer research

authors： Tsukeda H,Mizuno S,Nitta K

更新日期：1978-08-01 00:00:00

abstract：:Mutational synergism was examined in Chinese hamster V79 cells exposed to methyl methanesulfonate followed by N-acetoxy-2-acetylaminofluorene (AcAAF) at different time intervals. Treatment with 500 micron methyl methanesulfonate resulted in 95% survival of cloning ability and induced approximately 4 azaguanine-resista...

journal_title：Cancer research

authors： Myhr BC,DiPaolo JA

更新日期：1978-08-01 00:00:00

abstract：:The reactivity of normal and tumor host lymphocytes incubated with normal serum or with serum or malignant ascites fluid from tumor hosts was measured by the ability of the lymphocytes to synthesize ornithine decarboxylase after phytohemagglutinin stimulation. Each of three tumors tested (a solid fibrosarcoma, an asci...

journal_title：Cancer research

authors： Vaage J,Agarwal S,Reinertsen JL

更新日期：1978-08-01 00:00:00

abstract：:The effect of 17beta-estradiol on an estrogen receptor-positive human breast cancer cell line (MCF-7) was studied. Low concentrations (10(-9) M) of 17beta-estradiol enhanced the rate of cell proliferation; the overall cell cycle time was shortened; and the proportion of cells in the S phase increased. Higher concentra...

journal_title：Cancer research

authors： Weichselbaum RR,Hellman S,Piro AJ,Nove JJ,Little JB

更新日期：1978-08-01 00:00:00

abstract：:The adhesive characteristics of cultured acute lymphocytic leukemia cells (CCRF-CEM), lymphoma cells (Raji), and freshly isolated acute lymphocytic leukemia cells to human cultured endothelial cells were studied. An assay system was used whereby these neoplastic cells were allowed to interact with endothelial cells wh...

journal_title：Cancer research

authors： Maca RD,Fry GL,Hakes AD

更新日期：1978-08-01 00:00:00

abstract：:The relative contribution of lymphocytes, macrophages, and granulocytes to the cell content of primary 3-methyl-cholanthrene-induced murine fibrosarcomas was determined at different stages in their progression by differential cell analysis on enzyme-derived single-cell suspensions. Furthermore, immunohistological anal...

journal_title：Cancer research

authors： Wood GW,Gollahon KA

更新日期：1978-07-01 00:00:00

abstract：:Benzo(a)pyrene and 210Po were administered both simultaneously and sequentially by intratracheal instillations to Syrian golden hamsters in experiments designed to identify any synergistic interactions between these carcinogens. Their effects were additive after simultaneous administration. A significant synergistic i...

journal_title：Cancer research

authors： Little JB,McGandy RB,Kennedy AR

更新日期：1978-07-01 00:00:00

abstract：:The pancreatic carcinogen N-nitrosobis(2-oxopropyl)-amine was administered to Syrian golden hamsters after cholecystoduodenostomy and choledochostomy to investigate a possible bile reflux mechanism as a factor in pancreatic carcinogenesis. The induced lesions were similar in morphology, multiplicity, and distribution ...

journal_title：Cancer research

authors： Pour P,Donnelly T

更新日期：1978-07-01 00:00:00

abstract：:cis- and trans-diamminedichloroplatinum(II) (PDD) produced a DNA cross-linking effect in mouse leukemia L1210 cells, which was demonstrable after subtoxic treatments with the DNA alkaline elution technique. Cross-linking effects developed following treatments with concentrations as low as 1 micron for cis-PDD and 5 mi...

journal_title：Cancer research

authors： Zwelling LA,Kohn KW,Ross WE,Ewig RA,Anderson T

更新日期：1978-06-01 00:00:00